Role of carbon monoxide in heme-induced vasodilation

被引:46
作者
Kozma, F
Johnson, RA
Nasjletti, A
机构
[1] Department of Pharmacology, New York Medical College, Valhalla
关键词
vasomotor control; heme-L-lysinate; chromium mesoporphyrin;
D O I
10.1016/S0014-2999(97)00145-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the effects of carbon monoxide and heme-L-lysinate on the diameter of isolated, pressurized gracilis muscle arterioles. Both agents increased arteriolar diameter. The vasodilatory effect of heme-L-lysinate, but not of carbon monoxide was prevented by an inhibitor of heme oxygenase. Hence, heme-L-lysinate-induced vasodilation appears to be mediated by a product of vascular heme metabolism, presumably carbon monoxide. This implies that vascular formation of carbon monoxide may subserve a vasodilatory function.
引用
收藏
页码:R1 / R2
页数:2
相关论文
共 8 条
[1]   VASCULAR SMOOTH-MUSCLE CELL HEME OXYGENASES GENERATE GUANYLYL CYCLASE STIMULATORY CARBON-MONOXIDE [J].
CHRISTODOULIDES, N ;
DURANTE, W ;
KROLL, MH ;
SCHAFER, AI .
CIRCULATION, 1995, 91 (09) :2306-2309
[2]  
EWING JF, 1994, J PHARMACOL EXP THER, V271, P408
[3]  
FURCHGOTT RF, 1991, BLOOD VESSELS, V28, P52
[4]  
JOHNSONRA, 1996, AM J PHYSIOL, V271, pH1132
[5]   Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide [J].
Morita, T ;
Kourembanas, S .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2676-2682
[6]   CHARACTERISTICS AND ORIGIN OF MYOGENIC RESPONSE IN ISOLATED GRACILIS MUSCLE ARTERIOLES [J].
SUN, D ;
KALEY, G ;
KOLLER, A .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (03) :H1177-H1183
[7]  
VREMAN HJ, 1993, PEDIATR RES, V33, P195
[8]   Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation [J].
Zakhary, R ;
Gaine, SP ;
Dinerman, JL ;
Ruat, M ;
Flavahan, NA ;
Snyder, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) :795-798