Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide

被引：46

作者：

Xu, Jie ^{[1
]}

Li, Zhanting ^{[2
]}

Cao, Min ^{[1
]}

Zhang, Han ^{[2
]}

Sun, Jifeng ^{[2
]}

Zhao, Jie ^{[2
]}

Zhou, Qiang ^{[3
]}

Wu, Zhifen ^{[1
]}

Yang, Lianjia ^{[4
]}

机构：

[1] Fourth Mil Med Univ, Dept Periodontol & Oral Med, Sch Stomatol, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Div Nephrol, Tangdu Hosipital, Xian 710038, Peoples R China

[3] Fourth Mil Med Univ, Sch Stomatol, Dept Gen Dent & Emergency, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, Sch Stomatol, Dept Oral Histol & Pathol, Xian 710032, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Andrographis paniculata; Polysaccharide; Andrographolide; Diabetic nephropathy; Streptozotocin; NF-KAPPA-B; RATS; INHIBITION; CHROMATOGRAPHY; CONSTITUENTS; INFLAMMATION; ACTIVATION; EXTRACT; PROTEIN; SUGARS;

D O I：

10.1016/j.ijbiomac.2012.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A water-soluble polysaccharide (APP), with a molecular weight of 4.6 x 10(4) Da, was isolated from Andrographis paniculata and gas chromatography (GC) analysis showed APP was composed of galactose, mannose, fucose, arabinose and rhamnose with molar ratios of 15.4:2.5:4.3:1.5:1.6. The synergetic effect of APP in combination with andrographolide on renal complication in streptozotocin (STZ) induced diabetic mice was investigated. Wistar rats were made diabetic by injection of STZ, and APP and/or andrographolide was administered to diabetic mice for continuous two weeks. APP plus andrographolide not only increased the body weight and creatinine clearance rate (Ccr), but also decreased the levels of serum creatinine, serum urea nitrogen, urinary albumin excretion (UAE), serum urea and blood glucose in diabetic rats, as well as the relative kidney weight. In summary, APP plus andrographolide can improve the metabolic abnormalities of diabetic mice and prevent or delay the progression of diabetic renal complications, which may be useful as a therapeutic agent for inhibiting the progression of diabetic nephropathy. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：738 / 742

页数：5

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