Clinical significance of tumor-infiltrating lymphocytes in neoplastic progression and lymph node metastasis of human breast cancer

被引：52

作者：

Sheu, Bor-Ching ^{[1
]}

Kuo, Wen-Hung ^{[2
]}

Chen, Ruey-Jien ^{[1
]}

Huang, Su-Cheng ^{[1
]}

Chang, King-Jen ^{[2
]}

Chow, Song-Nan ^{[1
,3
]}

机构：

[1] Natl Taiwan Univ, Dept Obstet & Gynecol, Coll Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Dept Surg, Coll Med, Taipei 100, Taiwan

[3] Far Eastern Mem Hosp, Dept Obstet & Gynecol, Taipei 220, Taiwan

来源：

BREAST | 2008年 / 17卷 / 06期

关键词：

Breast cancers; Tumor-infiltrating lymphocytes; CD4/CD8; percentage; Lymph node metastasis;

D O I：

10.1016/j.breast.2008.06.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the clinical significance of tumor-infiltrating lymphocytes (TILs) within the tumor milieu, we quantitatively measured and compared the subpopulations of TILs in 24 patients with stage I-III breast carcinoma. Peripheral blood mononuclear cells (PBMCs), normal breast parenchyma-infiltrating lymphocytes (NILs), and TILs were isolated from tissue specimens and quantified by flow cytometry. The results showed that increased proportion of CD8(+) T cells. with decreased proportion of CD4(+) T cells, was significant in gated CD3(+) TILs as compared to autologous NILs or PBMCs (P < 0.001). The tumor-infiltrating CD8(+) T cells significantly increased with stage progression, reflected in a more strongly decreased CD4/CD8 percentage (P = 0.003). The CD4/CD8 percentage of TILs was strongly correlated with lymphovascular permeation and subsequent lymph node metastasis (P < 0.001). Increased percentages of tumor-infiltrating CD8(+) T cells with decreased CD4/CD8 percentages are of prognostic importance for cancer progression in human breast cancer. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：604 / 610

页数：7

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