Dynamics of gametocytes among Plasmodium falciparum clones in natural infections in an area of highly seasonal transmission

被引:74
作者
Abdel-Wahab, A
Abdel-Muhsin, AMA
Ali, E
Suleiman, S
Ahmed, S
Walliker, D
Babiker, HA
机构
[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland
[2] Univ Khartoum, Fac Med, Dept Biochem, Khartoum, Sudan
[3] Univ Khartoum, Natl Inst Res, Res Inst Trop Med, Khartoum, Sudan
基金
英国惠康基金; 英国医学研究理事会;
关键词
D O I
10.1086/340638
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The dynamics of gametocyte production in Plasmodium falciparum clones were studied in inhabitants of an area of highly seasonal malaria transmission in eastern Sudan. Reverse-transcriptase polymerase chain reaction was used to detect expression of 2 genes that encode gametocyte-specific proteins, pfs25 and pfg377, in parasites sampled from individuals throughout one year. Some patients who acquired infections during the wet season were found to harbor sub-patent gametocytemia through the following dry season in the apparent absence of mosquito transmission. Genotyping of parasites in multiclonal infections showed considerable fluctuation of gametocyte production by individual clones. The gametocytes present at the end of the dry season provide the most probable source of the genetically complex cyclical malaria outbreaks following the rainy season in this region.
引用
收藏
页码:1838 / 1842
页数:5
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