Biology of vascular endothelial growth factors

被引：455

作者：

Roy, Himadri

Bhardwaj, Shalini

Yla-Herttuala, Seppo

机构：

[1] Univ Kuopio, AI Virtanen Inst Mol Sci, Dept Biotechnol & Mol Med, FIN-70211 Kuopio, Finland

[2] Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland

[3] Kuopio Univ Hosp, Gene Therapy Unit, FIN-70211 Kuopio, Finland

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

VEGF; angiogenesis; signaling; diseases;

D O I：

10.1016/j.febslet.2006.03.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PIGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2879 / 2887

页数：9

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