Unanticipated outbreak of Q fever during a study using sheep, and its significance for further projects

被引：9

作者：

Henning, Klaus ^{[1
]}

Hotzel, Helmut ^{[2
]}

Peters, Martin ^{[3
]}

Welge, Peter ^{[4
]}

Popp, Walter ^{[5
]}

Theegarten, Dirk ^{[6
]}

机构：

[1] Friedrich Loeffler Inst, Inst Epidemiol, D-16868 Wusterhausen, Germany

[2] Friedrich Loeffler Inst, Jena, Germany

[3] Staatliches Veterinaruntersuchungsamt, Arnsberg, Germany

[4] Inst Ruhr Univ Bochum, BGFA Forsch Inst Arbeitsmed Deutsch Gesetzlichen, Bochum, Germany

[5] Univ Klinikum Essen, Krankenhaushyg, Essen, Germany

[6] Univ Klinikum Essen, Inst Pathol & Neuropathol, Essen, Germany

来源：

BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT | 2009年 / 122卷 / 1-2期

关键词：

Q fever; sheep diseases; Coxiella burnetii; Chlamydophila psittaci; Staphylococcus chromogenes; occupational health; zoonosis; COXIELLA-BURNETII; CHLAMYDIA; INFECTION;

D O I：

10.2376/0005-9366-122-13

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Effective measures for protection of laboratory staff against infections due to experiments with pathogens are a challenge for safeguarding against hazards. Investigations on limited epidemic infections and their causes are of high relevance. During an experiment with pregnant sheep 5 of 7 persons who took part in the operation procedures developed Q fever 10 to 24 days after exposure. One sheep aborted spontaneously 3 days after the third experiment. Examinations of the aborted material revealed Coxiella burnetii, Chlamydophila psittaci, and Staphylococcus chromogenes. Coxiella burnetii and Chlamydophila psittaci were also detected in some of the other placentae. This outbreak of Q fever during an experiment with infected sheep affected more than 70% of the people involved with this experiment and shows the high risk of working with the zoonotic agent Coxiella burnetii. Hence, technical, organizational, and personnel measures have to be taken, and laboratory animals are to be monitored to prevent further infections.

引用

页码：13 / 19

页数：7

共 25 条

[1] VACCINE PROPHYLAXIS OF Q-FEVER - A FOLLOW-UP-STUDY OF THE EFFICACY OF Q-VAX (CSL) 1985-1990 [J].

ACKLAND, JR ;

WORSWICK, DA ;

MARMION, BP .

MEDICAL JOURNAL OF AUSTRALIA, 1994, 160 (11) :704-708

[2] Shedding of Coxiella burnettii in ewes in two pregnancies following an episode of Coxiella abortion in a sheep flock [J].

Berri, M ;

Souriau, A ;

Crosby, M ;

Rodolakis, A .

VETERINARY MICROBIOLOGY, 2002, 85 (01) :55-60

[3] Relationships between the shedding of Coxiella burnetii, clinical signs and serological responses of 34 sheep [J].

Berri, M ;

Souriau, A ;

Crosby, M ;

Crochet, D ;

Lechopier, P ;

Rodolakis, A .

VETERINARY RECORD, 2001, 148 (16) :502-+

[4]

BROUQUI P, 2003, MANUAL CLIN MICROBIO, V1, P1030

[5] OCCUPATIONAL-HEALTH GUIDELINES FOR CONTROL OF Q-FEVER IN SHEEP RESEARCH [J].

HARRISON, RJ ;

VUGIA, DJ ;

ASCHER, MS .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 590 :283-290

[6] Changing epidemiology of Q fever in Germany, 1947-1999 [J].

Hellenbrand, W ;

Breuer, T ;

Petersen, L .

EMERGING INFECTIOUS DISEASES, 2001, 7 (05) :789-796

[7]

Henning K, 2000, TIERARZTL UMSCHAU, V55, P140

[8]

Henning K, 1999, TIERARZTL UMSCHAU, V54, P274

[9] Evidence of infection in tortoises by Chlamydia-like organisms that are genetically distinct from known Chlamydiaceae species [J].

Hotzel, H ;

Blahak, S ;

Diller, R ;

Sachse, K .

VETERINARY RESEARCH COMMUNICATIONS, 2005, 29 (Suppl 1) :71-80

[10] Coxiella burnetii infection [J].

Kazar, Jan .

RICKETTSIOSES: FROM GENOME TO PROTEOME, PATHOBIOLOGY, AND RICKETTSIAE AS AN INTERNATIONAL THREAT, 2005, 1063 :105-114

← 1 2 3 →