Asymmetric catalytic cyanosilylation of aldehydes using a chiral binaphthol-titanium complex

被引：95

作者：

Mori, M ^{[1
]}

Imma, H ^{[1
]}

Nakai, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT CHEM TECHNOL,TOKYO 152,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 35期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(97)01432-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric catalytic cyanosilylation of aliphatic aldehydes with Me3SiCN using (R)-BINOL-Ti(O-i-Pr)(2) as an asymmetric precatalyst is shown to proceed smoothly in dichloromethane to afford the cyanohydrins in relatively high enantioselectivity (up to 75% ee). (C) 1997 Elsevier Science Ltd.

引用

页码：6229 / 6232

页数：4

共 13 条

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