KA1(SO4)2•12H2O supported on silica gel as a novel heterogeneous system catalyzed biginelli reaction -: One-pot synthesis of di-hydropyrimidinones under solvent-free conditions

被引：119

作者：

Azizian, J ^{[1
]}

Mohammadi, AA ^{[1
]}

Karimi, AR ^{[1
]}

Mohammadizadeh, MR ^{[1
]}

机构：

[1] Shaheed Beheshti Univ, Fac Sci, Dept Chem, Tehran, Iran

来源：

APPLIED CATALYSIS A-GENERAL | 2006年 / 300卷 / 01期

关键词：

KA1(SO4)(2)center dot 12H(2)O-SiO2 (Alum-SiO2); Biginelli reaction; solvent-free conditions; di-hydropyrimidinones; 1,3-dicarbonyl; aldehydes; ketone; urea;

D O I：

10.1016/j.apcata.2005.11.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

3,4-Dihydropyrimidin-2(1H)-ones derivatives were synthesized in moderate to high yields in one-pot three component reaction from the corresponding aldehydos, ketones or 1,3-dicarbonyl compounds and urea, in the presence of catalytic amount of KAI(SO4)(2)(.)12H(2)O (Alum) supported on silica gel (Alum-SiO2) as a non-toxic, reusable, inexpensive and easily available reagent, under solvent-free conditions at 80 degrees C. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：85 / 88

页数：4