The molecular epidemiology of mumps virus

被引:68
作者
Muehlemann, Kathrin [1 ]
机构
[1] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland
关键词
Mumps; Mumps virus; Molecular epidemiology; Genotype; Vaccine;
D O I
10.1016/j.meegid.2004.02.003
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The molecular epidemiology of MuV is characterized by the co-existence of 10 (or more) distinct genotypes named A-J based on the nucleotide sequence of the SH gene. MuV show distinct geographic clustering. More than one genotype may circulate simultaneously in a geographic region. Limited data suggest redistribution of genotypes to occur over time. The selective forces remain speculative. Currently used vaccine strains belong to different genotypes. Some MuV genotypes (C, D, H, J) and vaccine strains (Urabe Am9) have been associated with enhanced neurovirulence. Also, reduced cross-neutralization capacity has been observed between genotype A and genotypes C and D. At present vaccine failure cannot be attributed to this phenomenon. Strain redistribution may lead to the emergence of new MuV strains with enhanced neurovirulence or reduced cross-neutralization capacity with current vaccine strains. Close monitoring of the genotype distribution of MuV and genotype-specific population immunity is needed in the vaccine era. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:215 / 219
页数:5
相关论文
共 64 条
  • [1] THE LYNN,JERYL VACCINE STRAIN OF MUMPS-VIRUS IS A MIXTURE OF 2 DISTINCT ISOLATES
    AFZAL, MA
    PICKFORD, AR
    FORSEY, T
    HEATH, AB
    MINOR, PD
    [J]. JOURNAL OF GENERAL VIROLOGY, 1993, 74 : 917 - 920
  • [2] Clustering of mumps virus isolates by SH gene sequence only partially reflects geographical origin
    Afzal, MA
    Buchanan, J
    Heath, AB
    Minor, PD
    [J]. ARCHIVES OF VIROLOGY, 1997, 142 (02) : 227 - 238
  • [3] Afzal MA, 1997, J MED VIROL, V52, P349, DOI 10.1002/(SICI)1096-9071(199708)52:4&lt
  • [4] 349::AID-JMV1&gt
  • [5] 3.0.CO
  • [6] 2-1
  • [7] Quantitative mutant analysis of viral quasispecies by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Amexis, G
    Oeth, P
    Abel, K
    Ivshina, A
    Pelloquin, F
    Cantor, CR
    Brau, A
    Chumakov, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) : 12097 - 12102
  • [8] Identification of a new genotype H wild-type mumps virus strain and its molecular relatedness to other virulent and attenuated strains
    Amexis, G
    Rubin, S
    Chatterjee, N
    Carbone, K
    Chumakov, K
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2003, 70 (02) : 284 - 286
  • [9] Sequence diversity of Jeryl Lynn strain of mumps virus: Quantitative mutant analysis for vaccine quality control
    Amexis, G
    Rubin, S
    Chizhikov, V
    Pelloquin, F
    Carbone, K
    Chumakov, K
    [J]. VIROLOGY, 2002, 300 (02) : 171 - 179
  • [10] Correlation of genetic variability with safety of mumps vaccine Urabe AM9 strain
    Amexis, G
    Fineschi, N
    Chumakov, K
    [J]. VIROLOGY, 2001, 287 (01) : 234 - 241