Heparinoids: Structure, biological activities and therapeutic applications

被引：51

作者：

Gunay, NS

Linhardt, RJ

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA

来源：

PLANTA MEDICA | 1999年 / 65卷 / 04期

关键词：

heparin; heparinoid; glycosaminoglycan; sulfated polysaccharide; therapeutic applications;

D O I：

10.1055/s-1999-13990

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Heparin is an important polyanionic drug having a wide variety of different biological activities. Substantial research effort has focused on the preparation of improved heparins and heparin analogues that might exhibit higher specificity and decreased side effects. These heparin analogues or heparinoids include sulfated polysaccharides from plant and animal origin, synthetic derivatives of polysaccharides, and acidic oligosaccharides and their small synthetic analogues. The structure, biological activities and therapeutic potential of these heparinoids are discussed.

引用

页码：301 / 306

页数：6

共 30 条

[1] Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate [J].