New cytotoxic saponins from Lysimachia davurica Ledeb.

被引：4

作者：

Tian, JK ^{[1
]}

Zou, ZM

Xu, LZ

Yang, SL

机构：

[1] Zhejiang Univ, Dept Chinese Med Sci & Engn, Hangzhou 310028, Peoples R China

[2] Chinese Acad Med Sci, Inst Med Plants Dev, Beijing 100094, Peoples R China

[3] Peking Union Med Coll, Beijing 100094, Peoples R China

来源：

JOURNAL OF INTEGRATIVE PLANT BIOLOGY | 2006年 / 48卷 / 02期

关键词：

davuricoside I and E; Lysimachia davurica; triterpene saponin;

D O I：

10.1111/j.1744-7909.2006.00223.x-i1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3 beta,16 alpha, 28, 29-tetrihydroxy-olean-12-en-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucuronopyranoside (compound 1) and 3 beta,16 alpha, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.

引用

页码：232 / 235

页数：4

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