Primate retina imaging with polarization-sensitive optical coherence tomography

被引:53
作者
Ducros, MG [1 ]
Marsack, JD [1 ]
Rylander, HG [1 ]
Thomsen, SL [1 ]
Milner, TE [1 ]
机构
[1] Univ Texas, Biomed Engn Program, Biomed Engn Laser Lab, Austin, TX 78712 USA
关键词
D O I
10.1364/JOSAA.18.002945
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Polarization-sensitive optical coherence tomography (PSOCT) is applied to determine the depth-resolved polarization state of light backreflected from the eye. The birefringence of the retinal nerve fiber layer (RNFL) was observed and measured from PSOCT images recorded postmortem in a Rhesus monkey. An image-processing algorithm was developed to identify birefringent regions in acquired PSOCT retinal images and automatically determine the thickness of the RNFL. Values of the RNFL thickness determined from histology and PSOCT were compared. PSOCT may provide a new method to determine RNFL thickness and birefringence for glaucoma diagnostics. (C) 2001 Optical Society of America
引用
收藏
页码:2945 / 2956
页数:12
相关论文
共 41 条
[1]  
[Anonymous], 1993, AM NAT STAND SAF US
[2]  
Chauhan DS, 1999, INVEST OPHTH VIS SCI, V40, P2332
[3]   Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography [J].
de Boer, JF ;
Milner, TE ;
Nelson, JS .
OPTICS LETTERS, 1999, 24 (05) :300-302
[4]   Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography [J].
deBoer, JF ;
Milner, TE ;
vanGemert, MJC ;
Nelson, JS .
OPTICS LETTERS, 1997, 22 (12) :934-936
[5]  
Ditchtl A, 1999, GREAFES ARCH CLIN EX, V237, P474
[6]  
DREHER AW, 1992, CLIN VISION SCI, V7, P481
[7]   Polarization sensitive optical coherence tomography of the rabbit eye [J].
Ducros, MG ;
de Boer, JF ;
Huang, HE ;
Chao, LC ;
Chen, ZP ;
Nelson, JS ;
Milner, TE ;
Rylander, HG .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1999, 5 (04) :1159-1167
[8]   Birefringence characterization of biological tissue by use of optical coherence tomography [J].
Everett, MJ ;
Schoenenberger, K ;
Colston, BW ;
Da Silva, LB .
OPTICS LETTERS, 1998, 23 (03) :228-230
[9]  
Fercher A F, 1996, J Biomed Opt, V1, P157, DOI 10.1117/12.231361
[10]   Effect of corneal polarization axis on assessment of retinal nerve fiber layer thickness by scanning laser polarimetry [J].
Greenfield, DS ;
Knighton, RW ;
Huang, XR .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 129 (06) :715-722