The alveolar macrophages in asthma: a double-edged sword

被引:159
作者
Balhara, J. [1 ]
Gounni, A. S. [1 ]
机构
[1] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada
关键词
PULMONARY INTRAVASCULAR MACROPHAGES; INTERSTITIAL MACROPHAGES; ALTERNATIVE ACTIVATION; AIRWAY HYPERREACTIVITY; ANTIGEN PRESENTATION; INCREASED EXPRESSION; CYTOKINE PRODUCTION; LUNG MACROPHAGES; DENDRITIC CELLS; PROLIFERATION;
D O I
10.1038/mi.2012.74
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Asthma is a complex disease of the lungs, which is characterized by airway inflammation and airway hyperresponsiveness (AHR). Alveolar macrophages (AMs), one of the prominent immune system cells found in the airways, have been implicated in the development and progression of asthma. AMs constitute a unique subset of pulmonary macrophages, which serve as a first line of defense against foreign invaders to the lung tissue. In addition, based on human and animal studies, they have also been found to regulate pro- and anti-inflammatory responses in the airways, suggesting that these cells have a critical role in asthma. In this review, our focus is to evaluate the relevance of AMs in the context of asthma, and the underlying mechanisms that regulate their functions.
引用
收藏
页码:605 / 609
页数:5
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共 70 条
[1]  
Alexis NE, 2001, AM J PHYSIOL-LUNG C, V280, pL369
[2]   Repeated exposure to ozone increases alveolar macrophage recruitment into asthmatic airways [J].
Arjomandi, M ;
Witten, A ;
Abbritti, E ;
Reintjes, K ;
Schmidlin, I ;
Zhai, WW ;
Solomon, C ;
Balmes, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (04) :427-432
[3]   Differential role of CD80 and CD86 on alveolar macrophages in the presentation of allergen to T lymphocytes in asthma [J].
Balbo, P ;
Silvestri, M ;
Rossi, GA ;
Crimi, E ;
Burastero, SE .
CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (04) :625-636
[4]   Alveolar macrophages modulate allergic inflammation in a murine model of asthma [J].
Bang, Bo-Ram ;
Chun, Eunyoung ;
Shim, Eun-Jin ;
Lee, Hyun-Seung ;
Lee, Soo-Yeon ;
Cho, Sang-Heon ;
Min, Kyung-Up ;
Kim, You-Young ;
Park, Heung-Woo .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2011, 43 (05) :275-280
[5]   INHIBITION OF THE IMMUNOSUPPRESSIVE ACTIVITY OF RESIDENT PULMONARY ALVEOLAR MACROPHAGES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR [J].
BILYK, N ;
HOLT, PG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1773-1777
[6]   EFFECT OF ACUTE INFLAMMATORY LUNG INJURY ON THE EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) IN RAT PULMONARY ALVEOLAR MACROPHAGES [J].
BRIELAND, JK ;
JONES, ML ;
CLARKE, SJ ;
BAKER, JB ;
WARREN, JS ;
FANTONE, JC .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 7 (02) :134-139
[7]   Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation to autologous TH2 lymphocytes [J].
Burastero, SE ;
Magnani, Z ;
Confetti, C ;
Abbruzzese, L ;
Oddera, S ;
Balbo, P ;
Rossi, GA ;
Crimi, E .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (06) :1136-1142
[8]   Antigen sensitization modulates alveolar macrophage functions in an asthma model [J].
Careau, É ;
Proulx, LI ;
Pouliot, P ;
Spahr, A ;
Turmel, V ;
Bissonnette, ÉY .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (05) :L871-L879
[9]   M1 and M2a Polarization of Human Monocyte-Derived Macrophages Inhibits HIV-1 Replication by Distinct Mechanisms [J].
Cassol, Edana ;
Cassetta, Luca ;
Rizzi, Chiara ;
Alfano, Massimo ;
Poli, Guido .
JOURNAL OF IMMUNOLOGY, 2009, 182 (10) :6237-6246
[10]   AIRWAY MACROPHAGES FROM PATIENTS WITH ASTHMA DO NOT PROLIFERATE [J].
CHANEZ, P ;
VAGO, P ;
DEMOLY, P ;
CORNILLAC, L ;
GODARD, P ;
BUREAU, JP ;
MICHEL, FB ;
BOUSQUET, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 92 (06) :869-877