Active immunization against Pneumocystis carinii with a recombinant P-catinii antigen

被引：39

作者：

Wells, J

Haidaris, CG

Wright, TW

Gigliotti, F

机构：

[1] Univ Rochester, Dept Pediat, Sch Med & Dent, Rochester, NY 14642 USA

[2] Univ Rochester, Dept Microbiol & Immunol, Sch Med & Dent, Rochester, NY 14642 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 04期

关键词：

D O I：

10.1128/IAI.74.4.2446-2448.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thiredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P carinii burdens after CD4(+) T-cell depletion and challenge with P. carinii.

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收藏

页码：2446 / 2448

页数：3

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