Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue

被引：75

作者：

Chien, Miao-Ping ^{[1
]}

Thompson, Matthew P. ^{[1
]}

Barback, Christopher V. ^{[2
]}

Ku, Ti-Hsuan ^{[1
]}

Hall, David J. ^{[2
]}

Gianneschi, Nathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Radiol, Sch Med, La Jolla, CA 92093 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 26期

关键词：

nanoparticles; enzyme-responsive; in vivo probe; micelle; peptide; CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; IN-VIVO; CANCER-CHEMOTHERAPY; MATRIX METALLOPROTEINASES; MICELLAR NANOPARTICLES; MOUSE MODEL; COPOLYMER; HYDROGEL; THERAPEUTICS;

D O I：

10.1002/adma.201300823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3599 / 3604

页数：6

共 56 条

[1] Enzymatically Triggered Self-Assembly of Block Copolymers [J].

Amir, Roey J. ;

Zhong, Sheng ;

Pochan, Darrin J. ;

Hawker, Craig J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (39) :13949-+

[2] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[3] Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers [J].

Azagarsamy, Malar A. ;

Sokkalingam, Punidha ;

Thayumanavan, S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (40) :14184-+

[4]

Bagshawe K.D., 1999, Enzyme-Prodrug Strategies for Cancer Therapy, P199

[5] Optical imaging of matrix metalloproteinase-2 activity in tumors: Feasibility study in a mouse model [J].

Bremer, C ;

Bredow, S ;

Mahmood, U ;

Weissleder, R ;

Tung, CH .

RADIOLOGY, 2001, 221 (02) :523-529

[6] ANTIBODY-CATALYZED PRODRUG ACTIVATION [J].

CAMPBELL, DA ;

GONG, B ;

KOCHERSPERGER, LM ;

YONKOVICH, S ;

GALLOP, MA ;

SCHULTZ, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :2165-2166

[7] PROTEASE-ACTIVATED PRODRUGS FOR CANCER-CHEMOTHERAPY [J].

CARL, PL ;

CHAKRAVARTY, PK ;

KATZENELLENBOGEN, JA ;

WEBER, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2224-2228

[8] Role of target geometry in phagocytosis [J].

Champion, JA ;

Mitragotri, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :4930-4934

[9] Fluorogenic enzyme-responsive micellar nanoparticles [J].

Chien, Miao-Ping ;

Thompson, Matthew P. ;

Lin, Eugene C. ;

Gianneschi, Nathan C. .

CHEMICAL SCIENCE, 2012, 3 (09) :2690-2694

[10] Folate-conjugated thermoresponsive block copolymers: Highly efficient conjugation and solution self-assembly [J].

De, Priyadarsi ;

Gondi, Sudershan R. ;

Sumerlin, Brent S. .

BIOMACROMOLECULES, 2008, 9 (03) :1064-1070

← 1 2 3 4 5 6 →