Asymmetric cycloisomerization of 1,6-and 1,7-enynes by transition-metal catalysts

被引：149

作者：

Fairlamb, IJS ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 09期

关键词：

atom economy; cyclization; enantioselectivity; palladium; rhodium; ruthenium;

D O I：

10.1002/anie.200301699

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly functionalized carbo- and heterocycles can be prepared enantioselectively from simple enynes in transition-metal-catalyzed reactions. This versatile, atom-economic, and environmentally friendly approach has become a mainstay in natural product synthesis. The concise synthesis of (+)-pilocarpine is one example (see scheme). binap = 2,2′-bis- (diphenylphosphanyl)-1,1′-binaphthyl), cod = cyclooctacliene, RT = room temperature.

引用

页码：1048 / 1052

页数：5

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