Waist circumference is an independent predictor of insulin resistance in black and white youths

被引:222
作者
Lee, S [1 ]
Bacha, F [1 ]
Gungor, N [1 ]
Arslanian, SA [1 ]
机构
[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Div Pediat Endocrinol Metab & Diabet Mellitus, Sch Med,Weight Management & Wellness Ctr, Pittsburgh, PA 15213 USA
关键词
D O I
10.1016/j.jpeds.2005.10.001
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objectives We examined how well waist circumference (WC) reflects total and abdominal fat and whether WC predicts insulin resistance independent of body mass index (BMI) percentile in youths. Study design Body composition was measured by dual-energy x-ray absorptiometry and abdominal adiposity by computed tomography. Insulin sensitivity was measured by the hvperinsulinemic-euglycemic clamp. Results Both BMI percentile and WC were significantly associated (P < .01) with total and abdominal fat and insulin sensitivity. WC remained a significant (P < .01) correlate of total and abdominal fat and insulin sensitivity after controlling for BMI percentile. By contrast, BMI percentile did not remain a significant correlate of visceral fat and markers of insulin resistance after controlling for WC. Without exception, WC explained a greater variance in abdominal fat and metabolic profiles than did BMI percentile. Conclusions Our findings suggest that the prediction of health risks associated with obesity in youths is improved by the additional inclusion of WC measure to the BMI percentile. Such observations would reinforce the importance of including WC in the assessment of childhood obesity to identify those at increased metabolic risk due to excess abdominal fat.
引用
收藏
页码:188 / 194
页数:7
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