Different stereochemistry for the reduction of trifluoromethyl ketones and methyl ketones catalyzed by alcohol dehydrogenase from Geotrichum

被引：32

作者：

Nakamura, K ^{[1
]}

Matsuda, T ^{[1
]}

Itoh, T ^{[1
]}

Ohno, A ^{[1
]}

机构：

[1] OKAYAMA UNIV,FAC EDUC,DEPT CHEM,OKAYAMA 700,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

关键词：

D O I：

10.1016/0040-4039(96)01211-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of trifluoromethyl ketones by a crude alcohol dehydrogenase from Geotrichum affords (S)-trifluoromethyl carbinols in excellent ee, whereas the reduction of methyl ketones gives the corresponding alcohols of the opposite configuration in excellent ee. Copyright (C) 1996 Elsevier Science Ltd.

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页码：5727 / 5730

页数：4

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