Alteration of transcription factors NF-kappa B and STAT1 in Alzheimer's disease brains

被引：89

作者：

Kitamura, Y

Shimohama, S

Ota, T

Matsuoka, Y

Nomura, Y

Taniguchi, T

机构：

[1] KYOTO UNIV, FAC MED, DEPT NEUROL, KYOTO 606, JAPAN

[2] KYOTO PHARMACEUT UNIV, DEPT NEUROBIOL, KYOTO 607, JAPAN

[3] HOKKAIDO UNIV, FAC PHARMACEUT SCI, DEPT PHARMACOL, SAPPORO, HOKKAIDO 060, JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 237卷 / 01期

关键词：

Alzheimer's disease; temporal cortex; inflammatory activation; transcription factors; nuclear factor-kappa B; signal transducer and activator of transcription-1 alpha; inducible nitric oxide synthase;

D O I：

10.1016/S0304-3940(97)00797-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies suggest that inflammatory activation occurs in the brains of patients with Alzheimer's disease (AD). Several transcription factors such as nuclear factor-kappa B (NF-kappa B) and signal transducer and activator of transcription-1 (STAT1) may be activated in glial cells by a number of cytokines and then translocated from the cytosol to the nucleus. We assessed NF-kappa B and STAT1 in temporal cortex from normal and AD brains using specific antibodies. NF-kappa B p65 in the particulate fraction and STAT1 alpha in both the particulate and cytosolic fractions were more abundant in AD cases than in controls. These findings suggest that the increased NF-kappa B and STAT1 alpha in cell nuclei may be involved in inflammatory activation in AD brains. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：17 / 20

页数：4

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