mTOR signaling for biological control and cancer

被引：131

作者：

Alayev, Anya ^{[1
]}

Holz, Marina K. ^{[1
,2
,3
]}

机构：

[1] Yeshiva Univ, Dept Biol, Stern Coll Women, New York, NY 10016 USA

[2] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY USA

[3] Albert Einstein Canc Ctr, Bronx, NY USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2013年 / 228卷 / 08期

关键词：

MESSENGER-RNA TRANSLATION; TUBEROUS SCLEROSIS COMPLEX; TUMOR-SUPPRESSOR COMPLEX; POSITIVE BREAST-CANCER; AMINO-ACID SUFFICIENCY; DIET-INDUCED OBESITY; CELL-GROWTH CONTROL; RICH AKT SUBSTRATE; EXTENDS LIFE-SPAN; P70; S6; KINASE;

D O I：

10.1002/jcp.24351

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian target of rapamycin (mTOR) is a major intersection that connects signals from the extracellular milieu to corresponding changes in intracellular processes. When abnormally regulated, the mTOR signaling pathway is implicated in a wide spectrum of cancers, neurological diseases, and proliferative disorders. Therefore, pharmacological agents that restore the regulatory balance of the mTOR pathway could be beneficial for a great number of diseases. This review summarizes current understanding of mTOR signaling and some unanswered questions in the field. We describe the composition of the mTOR complexes, upstream signals that activate mTOR, and physiological processes that mTOR regulates. We also discuss the role of mTOR and its downstream effectors in cancer, obesity and diabetes, and autism. J. Cell. Physiol. 228: 16581664, 2013. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1658 / 1664

页数：7

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