Activated Protein C-Protein C Inhibitor Complex in Patients With Abdominal Aortic Aneurysms: Is It Associated With Diameter and Growth Rate?

被引：16

作者：

Koelbel, Tilo ^{[1
]}

Strandberg, Karin ^{[2
]}

Donath, Tobias ^{[1
]}

Mattiasson, Ingrid ^{[1
]}

Stenflo, Johan ^{[2
]}

Lindblad, Bengt ^{[1
]}

机构：

[1] Malmo Univ Hosp, Dept Vasc Dis, S-20502 Malmo, Sweden

[2] Malmo Univ Hosp, Dept Clin Chem, S-20502 Malmo, Sweden

来源：

VASCULAR AND ENDOVASCULAR SURGERY | 2008年 / 42卷 / 02期

基金：

英国医学研究理事会;

关键词：

aorta; aneurysm; coagulation; thrombus;

D O I：

10.1177/1538574407311108

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Increased thrombin activation was documented in patients with abdominal aortic aneurysm (AAA). Activated protein C-protein C inhibitor (APC-PCI) complex, a new biological marker of thrombin generation, was measured in a population of 232 patients with AAA and a control group, and the association between aneurysm size, growth rate, and APC-PCI was studied. The patients were divided into cohorts according to AAA diameter and compared with a control group. APC-PCI was significantly higher in all AAA cohorts (n = 232; median, 0.36 mu g/L; 10th to 90th percentile, 0.18-1.01) compared with the control group (n = 41; median, 0.19 mu g/L; 10th to 90th percentile, 0.11-0.31; P <= .001). APC-PCI correlated with AAA diameter (r = .22; P = .001), body mass index (r = -.19; P = .004), and age (r = .19; P = .004). APC-PCI did not correlate with AAA growth rate (r = .11; P = .14).

引用

页码：135 / 140

页数：6

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