Cannabinoid Hyperemesis Relieved by Compulsive Bathing

被引：75

作者：

Chang, Yoon Hee ^{[1
]}

Windish, Donna M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Yale Primary Care Internal Med Residency Program, New Haven, CT 06510 USA

来源：

MAYO CLINIC PROCEEDINGS | 2009年 / 84卷 / 01期

关键词：

USE DISORDERS; DELTA(9)-TETRAHYDROCANNABINOL; PREVALENCE; HUMANS;

D O I：

10.4065/84.1.76

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cannabinoid hyperemesis is a clinical syndrome characterized by repeated vomiting and associated learned compulsive hot water bathing behavior due to long-term marijuana use. Research has indentified type 1 cannabinoid receptors in the intestinal nerve plexus that have an inhibitory effect on gastrointestinal motility. This Inhibitory effect may lead to hyperemesis In marijuana users. The thermoregulatory role of endocannabinoids may be responsible for the patient's need to take hot showers. We report 2 cases of cannabinoid hyperemesis that demonstrate this unusual adverse effect of marijuana use.

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页码：76 / 78

页数：3

相关论文

共 17 条

[1] METOCLOPRAMIDE - PHARMACOLOGY AND CLINICAL-APPLICATION [J].

ALBIBI, R ;

MCCALLUM, RW .

ANNALS OF INTERNAL MEDICINE, 1983, 98 (01) :86-95

[2] Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse [J].

Allen, JH ;

de Moore, GM ;

Heddle, R ;

Twartz, JC .

GUT, 2004, 53 (11) :1566-1570

[3] Thermoregulation - Recent concepts and remaining questions [J].

Benarroch, Eduardo E. .

NEUROLOGY, 2007, 69 (12) :1293-1297

[4] Prevalence of marijuana use disorders in the United States - 1991-1992 and 2001-2002 [J].

Compton, WM ;

Grant, BF ;

Colliver, JD ;

Glantz, MD ;

Stinson, FS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (17) :2114-2121

[5] Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function [J].

Cota, Daniela ;

Steiner, Michel-Alexander ;

Marsicano, Giovanni ;

Cervino, Cristina ;

Herman, James P. ;

Gruebler, Yvonne ;

Stalla, Johanna ;

Pasquali, Renato ;

Lutz, Beat ;

Stalla, Guenter K. ;

Pagotto, Uberto .

ENDOCRINOLOGY, 2007, 148 (04) :1574-1581

[6] The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by Δ9-tetrahydrocannabinol and other cannnabinoids [J].

Darmani, NA .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (01) :34-42

[7] The emerging role of cannabinoid neuromodulators in symptom management [J].

Davis, Mellar ;

Maida, Vincent ;

Daeninck, Paul ;

Pergolizzi, Joseph .

SUPPORTIVE CARE IN CANCER, 2007, 15 (01) :63-71

[8] Cortical, thalamic, and hypothalamic responses to cooling and warming the skin in awake humans: A positron-emission tomography study [J].

Egan, GF ;

Johnson, J ;

Farrell, M ;

McAllen, R ;

Zamarripa, F ;

McKinley, MJ ;

Lancaster, J ;

Denton, D ;

Fox, PT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5262-5267

[9]

Hasler WL, 2008, HARRISONS PRINCIPLES

[10] Cannabidiol potentiates pharmacological effects of Δ9-tetrahydrocannabinol via CB1 receptor-dependent mechanism [J].

Hayakawa, Kazuhide ;

Mishima, Kenichi ;

Hazekawa, Mai ;

Sano, Kazunori ;

Irie, Keiichi ;

Orito, Kensuke ;

Egawa, Takashi ;

Kitamura, Yoshihisa ;

Uchida, Naoki ;

Nishimura, Ryoji ;

Egashira, Nobuaki ;

Iwasaki, Katsunori ;

Fujiwara, Michihiro .

BRAIN RESEARCH, 2008, 1188 :157-164