Insulin-like growth factor-I, cognition and brain aging

被引：108

作者：

van Dam, PS

Aleman, A

机构：

[1] Onze Lieve Vrouw Hosp, Dept Internal Med, NL-1090 HM Amsterdam, Netherlands

[2] Univ Utrecht, Med Ctr, Dept Clin Endocrinol, Utrecht, Netherlands

[3] Univ Utrecht, Med Ctr, Dept Psychiat, Utrecht, Netherlands

[4] Univ Utrecht, Helmholtz Inst, Psychol Lab, Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 490卷 / 1-3期

关键词：

insulin-like growth factor-I; growth hormone; aging; cognition;

D O I：

10.1016/j.ejphar.2004.02.047

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aging is associated with a decline in the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. As aging also coincides with a decline in specific cognitive functions and as some of these dysfunctions are also observed in subjects with GH deficiency, it has been hypothesised that a causal relationship exists between the reduction in circulating GH and/or IGF-I and the observed cognitive deficits in the elderly. The present review summarises the available data concerning the possible relation between GH, IGF-I and cognitive performance, and regarding possible underlying pathophysiological mechanisms. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：87 / 95

页数：9

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