APOBEC3G encapsidation into HIV-1 virions: which RNA is it?

被引:41
作者
Strebel, Klaus [1 ]
Khan, Mohammad A. [1 ]
机构
[1] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1186/1742-4690-5-55
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates singlestranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved.
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