Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein

被引：44

作者：

Larralde, O

Smith, RWP

Wilkie, GS

Malik, P

Gray, NK ^{[1
]}

Clements, JB

机构：

[1] Univ Edinburgh, MRC, Human Genet Unit, Western Gen Hosp, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Sch Mol & Clin Med, Outpatients Dept 3rd Floor, Western Gen Hosp, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Univ Glasgow, Div Virol, Inst Biomed & Life Sci, Glasgow G11 5JR, Lanark, Scotland

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/JVI.80.3.1588-1591.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential regulator of viral gene expression with roles at various levels of RNA metabolism in the nucleus. Using the tethered function assay, we showed a cytoplasmic activity for ICP27 in directly enhancing mRNA translation in vivo in the absence of other viral factors. The region of ICP27 required for translational stimulation maps to the C terminus. Furthermore, in infected cells, ICP27 is associated with polyribosomes, indicating a function in translation during the lytic cycle.

引用

收藏

页码：1588 / 1591

页数：4

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