Molecular surveillance for multidrug-resistant Plasmodium falciparum Cambodia

被引：26

作者：

Shah, Naman K. ^{[1
]}

Alker, Alisa P. ^{[1
]}

Sem, Rithy ^{[2
,3
]}

Susanti, Agustina Ika ^{[4
]}

Muth, Sinuon ^{[2
]}

Maguire, Jason D. ^{[4
]}

Duong, Socheat ^{[2
]}

Ariey, Frederic ^{[3
]}

Meshnick, Steven R. ^{[1
]}

Wongsrichanalai, Chansuda ^{[4
]}

机构：

[1] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA

[2] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia

[3] Pasteur Inst Cambodia, Phnom Penh, Indonesia

[4] USN, Med Res Unit 2, Jakarta, Indonesia

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3201/eid1410.080080

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

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收藏

页码：1637 / 1640

页数：4

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