The role of transcription-independent damage signals in the initiation of epithelial wound healing

被引：212

作者：

Cordeiro, Joao V. ^{[1
]}

Jacinto, Antonio ^{[1
]}

机构：

[1] Univ Nova Lisboa, Ctr Estudos Doencas Cron CEDOC, Fac Ciencias Med, P-1169056 Lisbon, Portugal

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 04期

基金：

欧洲研究理事会;

关键词：

INDUCED ATP RELEASE; NITRIC-OXIDE; HYDROGEN-PEROXIDE; GROWTH-FACTORS; BLOOD-CELLS; MECHANICAL TENSION; INDUCE CHEMOTAXIS; MOLECULAR-PATTERN; EXTRACELLULAR ATP; IMMUNE-RESPONSE;

D O I：

10.1038/nrm3541

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wound healing is an essential biological process that comprises sequential steps aimed at restoring the architecture and function of damaged cells and tissues. This process begins with conserved damage signals, such as Ca2+, hydrogen peroxide (H2O2) and ATP, that diffuse through epithelial tissues and initiate immediate gene transcription-independent cellular effects, including cell shape changes, the formation of functional actomyosin structures and the recruitment of immune cells. These events integrate the ensuing transcription of specific wound response genes that further advance the wound healing response. The immediate importance of transcription-independent damage signals illustrates that healing a wound begins as soon as damage occurs.

引用

页码：249 / 262

页数：14

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