Synthesis and characterization of a new isocyanato carborane anion [7-0=C=N-7-CB10H12](-); Study on its reactivity toward amino containing compounds

被引：14

作者：

Arterburn, JB ^{[1
]}

Wu, Y ^{[1
]}

Quintana, W ^{[1
]}

机构：

[1] NEW MEXICO STATE UNIV,DEPT CHEM & BIOCHEM,LAS CRUCES,NM 88003

来源：

POLYHEDRON | 1996年 / 15卷 / 24期

基金：

美国国家科学基金会;

关键词：

carborane; amino acids; isocyanate; boron; neutron; capture;

D O I：

10.1016/0277-5387(96)00239-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The new isocyanato carborane anion, [7-O=C=N-7-CB10H12](-) was prepared by the reaction of 7-H3N-7-CB10H12 with triphosgene in the presence of triethylamine. The structure of this compound was established by H-1, B-11 and C-13 NMR as well as IR spectroscopy. The reactivity of this compound with a series of organic amines was investigated. The resulting ureas were obtained in good to excellent yields. This approach is suitable for development of compounds for use in tumor selective Boron Neutron Capture Therapy (BNCT). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：4355 / 4359

页数：5

共 14 条

[1] BORON NEUTRON-CAPTURE THERAPY - LINKAGE OF A BORONATED MACROMOLECULE TO MONOCLONAL-ANTIBODIES DIRECTED AGAINST TUMOR-ASSOCIATED ANTIGENS [J].

ALAM, F ;

SOLOWAY, AH ;

BARTH, RF ;

MAFUNE, N ;

ADAMS, DM ;

KNOTH, WH .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (10) :2326-2330

[2]

BARTH R, 1992, PROGR NEUTRON CAPTUR

[3] BORONATED STARBURST DENDRIMER MONOCLONAL-ANTIBODY IMMUNOCONJUGATES - EVALUATION AS A POTENTIAL DELIVERY SYSTEM FOR NEUTRON-CAPTURE THERAPY [J].

BARTH, RF ;

ADAMS, DM ;

SOLOWAY, AH ;

ALAM, F ;

DARBY, MV .

BIOCONJUGATE CHEMISTRY, 1994, 5 (01) :58-66

[4]

BARTH RF, 1992, CANCER-AM CANCER SOC, V70, P2995

[5] TRIPHOSGENE, A CRYSTALLINE PHOSGENE SUBSTITUTE [J].

ECKERT, H ;

FORSTER, B .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1987, 26 (09) :894-895

[6] THE ROLE OF CHEMISTRY IN THE DEVELOPMENT OF BORON NEUTRON-CAPTURE THERAPY OF CANCER [J].

HAWTHORNE, MF .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (07) :950-984

[7] PREPARATION OF B10CH13- DERIVATIVES BY CARBON ATOM INSERTION WITH ALKYL ISOCYANIDES [J].

HYATT, DE ;

OWEN, DA ;

TODD, LJ .

INORGANIC CHEMISTRY, 1966, 5 (10) :1749-&

[8] SYNTHESIS OF NEW BUILDING-BLOCKS FOR BORON-RICH OLIGOMERS IN BORON NEUTRON-CAPTURE THERAPY (BNCT) .2. MONOMERS DERIVED FROM 2,2-DISUBSTITUTED-1,3-DIOLS [J].

KIM, YS ;

KANE, RR ;

BENO, CL ;

ROMANO, S ;

MENDEZ, G ;

HAWTHORNE, MF .

TETRAHEDRON LETTERS, 1995, 36 (29) :5147-5150

[9] B10H12CNH3, B9H9CH-, B11H11CH-, AND METALLOMONOCARBORANES [J].

KNOTH, WH .

INORGANIC CHEMISTRY, 1971, 10 (03) :598-&

[10]

KNOTH WH, 1968, INORG SYNTH, V11, P33

← 1 2 →