Targeted Drug Delivery and Penetration Into Solid Tumors

被引：93

作者：

Corti, Angelo ^{[1
,2
]}

Pastorino, Fabio ^{[3
]}

Curnis, Flavio ^{[1
,2
]}

Arap, Wadih ^{[4
]}

Ponzoni, Mirco ^{[3
]}

Pasqualini, Renata ^{[4
]}

机构：

[1] Ist Sci San Raffaele, Div Mol Oncol, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, IIT Network Res Unit Mol Neurosci, I-20132 Milan, Italy

[3] G Gaslini Childrens Hosp, Lab Oncol, Expt Therapy Unit, Genoa, Italy

[4] Univ Texas MD Anderson Canc Ctr, David H Koch Ctr, Houston, TX 77030 USA

来源：

MEDICINAL RESEARCH REVIEWS | 2012年 / 32卷 / 05期

关键词：

chemotherapy; doxorubicin; liposomes; vascular targeting; NGR; NGR-hTNF; NGR-TNF; CD13; av ss 3 integrin; isoDGR; ISOLATED LIMB PERFUSION; NECROSIS-FACTOR-ALPHA; PEGYLATED-LIPOSOMAL DOXORUBICIN; SYNERGISTIC ANTITUMOR-ACTIVITY; NEOVASCULATURE-HOMING MOTIF; AMINOPEPTIDASE-N; INTERFERON-GAMMA; MOUSE MODEL; NGR-HTNF; CANCER;

D O I：

10.1002/med.20238

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Delivery and penetration of chemotherapeutic drugs into tumors are limited by a number of factors related to abnormal vasculature and altered stroma composition in neoplastic tissues. Coupling of chemotherapeutic drugs with tumor vasculature-homing peptides or administration of drugs in combination with biological agents that affect the integrity of the endothelial lining of tumor vasculature is an appealing strategy to improve drug delivery to tumor cells. Promising approaches to achieve this goal are based on the use of Asn-Gly-Arg (NGR)-containing peptides as ligands for drug delivery and of NGR-TNF, a peptide-tumor necrosis factor-a fusion protein that selectively alters drug penetration barriers and that is currently tested in a randomized Phase III trial in patients with malignant pleural mesothelioma.

引用

页码：1078 / 1091

页数：14

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