Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

被引:61
作者
Bonifati, V
Breedveld, GJ
Squitieri, F
Vanacore, N
Brustenghi, P
Harhangi, BS
Montagna, P
Cannella, M
Fabbrini, G
Rizzu, P
van Duijn, CM
Oostra, BA
Meco, G
Heutink, P
机构
[1] Erasmus Univ, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands
[2] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy
[3] IRCCS Neuromed, Neurogenet Unit, Pozzilli, Italy
[4] Foligno Hosp, Div Neurol, Foligno, Italy
[5] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands
[6] Univ Bologna, Neurol Inst, Bologna, Italy
关键词
D O I
10.1002/ana.10106
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome lp.
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页码:253 / 256
页数:4
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