Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset

被引：61

作者：

Bonifati, V

Breedveld, GJ

Squitieri, F

Vanacore, N

Brustenghi, P

Harhangi, BS

Montagna, P

Cannella, M

Fabbrini, G

Rizzu, P

van Duijn, CM

Oostra, BA

Meco, G

Heutink, P

机构：

[1] Erasmus Univ, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

[2] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy

[3] IRCCS Neuromed, Neurogenet Unit, Pozzilli, Italy

[4] Foligno Hosp, Div Neurol, Foligno, Italy

[5] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[6] Univ Bologna, Neurol Inst, Bologna, Italy

来源：

ANNALS OF NEUROLOGY | 2002年 / 51卷 / 02期

关键词：

D O I：

10.1002/ana.10106

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome lp.

引用

页码：253 / 256

页数：4

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