Geometry of proteins: Hydrogen bonding, sterics, and marginally compact tubes

被引：13

作者：

Banavar, JR ^{[1
]}

Cieplak, M

Flammini, A

Hoang, TX

Kamien, RD

Lezon, T

Marenduzzo, D

Maritan, A

Seno, F

Snir, Y

Trovato, A

机构：

[1] Penn State Univ, Dept Phys, Davey Lab 104, University Pk, PA 16802 USA

[2] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

[3] Indiana Univ, Sch Informat, Bloomington, IN 47408 USA

[4] VAST, Inst Phys & Elect, Hanoi, Vietnam

[5] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[6] Univ Warwick, Inst Math, Coventry CV4 7AL, W Midlands, England

[7] Univ Padua, Dipartimento Fis G Galilei, I-35131 Padua, Italy

[8] Univ Padua, Sez INFN, I-35131 Padua, Italy

来源：

PHYSICAL REVIEW E | 2006年 / 73卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevE.73.031921

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

The functionality of proteins is governed by their structure in the native state. Protein structures are made up of emergent building blocks of helices and almost planar sheets. A simple coarse-grained geometrical model of a flexible tube barely subject to compaction provides a unified framework for understanding the common character of globular proteins. We argue that a recent critique of the tube idea is not well founded.

引用

页数：5

共 56 条

[1] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[2]

[Anonymous], DIFFERENT U REINVENT

[3]

Banavar Jayanth R., 2003, ComPlexUs, V1, P4, DOI 10.1159/000067638

[4] Unified perspective on proteins: A physics approach [J].

Banavar, JR ;

Hoang, TX ;

Maritan, A ;

Seno, F ;

Trovato, A .

PHYSICAL REVIEW E, 2004, 70 (04) :25

[5] Lattice tube model of proteins [J].

Banavar, JR ;

Cieplak, M ;

Maritan, A .

PHYSICAL REVIEW LETTERS, 2004, 93 (23) :238101-1

[6] Colloquium:: Geometrical approach to protein folding:: a tube picture [J].

Banavar, JR ;

Maritan, A .

REVIEWS OF MODERN PHYSICS, 2003, 75 (01) :23-34

[7] Geometry and physics of proteins [J].

Banavar, JR ;

Maritan, A ;

Micheletti, C ;

Trovato, A .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2002, 47 (03) :315-322

[8] Structure of proteins [J].

Bernal, JD .

NATURE, 1939, 143 :663-667

[9] DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS [J].

BOWIE, JU ;

REIDHAAROLSON, JF ;

LIM, WA ;

SAUER, RT .

SCIENCE, 1990, 247 (4948) :1306-1310

[10] THE ROLE OF TURNS IN THE STRUCTURE OF AN ALPHA-HELICAL PROTEIN [J].

BRUNET, AP ;

HUANG, ES ;

HUFFINE, ME ;

LOEB, JE ;

WELTMAN, RJ ;

HECHT, MH .

NATURE, 1993, 364 (6435) :355-358

← 1 2 3 4 5 6 →