Meniscal allograft transplantation

Because of the knee pain and arthritic changes that can occur with excision of the meniscus, meniscal transplantation has been explored as a means to decrease or prevent these sequelae. Knowledge of immunology and methods of preservation and sterilization is needed to assess the feasibility of the procedure. Experimental studies have found that the allografts can heal, repopulate with host cells, and have normal appearance. Early clinical evidence has shown meniscal allografts can be successful in decreasing patients' symptoms and increasing their activities. However, strict patient selection criteria are required for success. With the studies to date lacking long-term follow-up, cautious optimism is appropriate because of concerns over graft durability and capacity to impede arthritis.