Neurodevelopmental processes and psychological functioning in autism

被引:38
作者
Gillberg, C [1 ]
机构
[1] Univ Gothenburg, Dept Child & Adolescent Psychiat, Annedals Clins, S-41345 Gothenburg, Sweden
关键词
D O I
10.1017/S0954579499002217
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Autism is a developmental disorder with variable severity, occurring at all levels of cognitive ability and having a number of slightly different clinical presentations. It is associated with neuropsychological deficits that occur in other conditions also, but its pattern may be specific to autism. Genetic and environmental early insults to brain development are etiological determinants of the disorder. Brain circuitries important for social, communicative, and integrational purposes have been suggested to be dysfunctional in autism. There could be at least two different pathways to autism, one connected with primary temporofrontal dysfunction (and late prenatal-early postnatal origins) and another linked to primary brain-stem dysfunction (and early prenatal origins). Further study of neurodevelopmental and neuropsychological processes in autism will help elucidate not only the pathological mechanisms involved in the specific syndromes but also the underpinnings of normal brain development.
引用
收藏
页码:567 / 587
页数:21
相关论文
共 157 条
[1]   GLIAL FIBRILLARY ACIDIC PROTEIN IN THE CEREBROSPINAL-FLUID OF CHILDREN WITH AUTISM AND OTHER NEUROPSYCHIATRIC DISORDERS [J].
AHLSEN, G ;
ROSENGREN, L ;
BELFRAGE, M ;
PALM, A ;
HAGLID, K ;
HAMBERGER, A ;
GILLBERG, C .
BIOLOGICAL PSYCHIATRY, 1993, 33 (10) :734-743
[2]  
AICARDI J, 1998, DIS NERVOUS SYSTEM C, P897
[3]   A COMPARISON OF PATTERNS OF DISABILITY IN SEVERELY MENTALLY-HANDICAPPED CHILDREN OF DIFFERENT ETHNIC-ORIGINS [J].
AKINSOLA, HA ;
FRYERS, T .
PSYCHOLOGICAL MEDICINE, 1986, 16 (01) :127-133
[4]  
[Anonymous], EUROPEAN CHILD ADOLE
[5]  
Aronson M, 1997, DEV MED CHILD NEUROL, V39, P583
[6]   CHILDHOOD-ONSET DEPRESSIVE-DISORDERS - A FOLLOW-UP-STUDY OF RATES OF REHOSPITALIZATION AND OUT-OF-HOME PLACEMENT AMONG CHILD PSYCHIATRIC-INPATIENTS [J].
ASARNOW, JR ;
GOLDSTEIN, MJ ;
CARLSON, GA ;
PERDUE, S ;
BATES, S ;
KELLER, J .
JOURNAL OF AFFECTIVE DISORDERS, 1988, 15 (03) :245-253
[7]   The ''autistic psychopathy'' in childhood [J].
Asperger, H .
ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1944, 117 (01) :76-136
[8]  
Bailey A, 1998, HUM MOL GENET, V7, P571
[9]   Autism: Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives [J].
Bailey, A ;
Phillips, W ;
Rutter, M .
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 1996, 37 (01) :89-126
[10]  
Baron-Cohen Simon, 1995, MINDBLINDNESS ESSAY, DOI DOI 10.7551/MITPRESS/4635.001.0001