Cascade radical cyclisations of imines

被引：35

作者：

Bowman, WR ^{[1
]}

Stephenson, PT ^{[1
]}

Young, AR ^{[1
]}

机构：

[1] PFIZER LTD,CENT RES,DEPT DISCOVERY CHEM,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 35期

关键词：

D O I：

10.1016/0040-4020(96)00636-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cascade radical reactions, initiated by cyclisation of sp(3) carbon-centred radicals onto the C-atom of imines, have been used to develop a new protocol for the synthesis of a range of nitrogen heterocycles. The C-centred radical intermediates were generated from benzeneselenyl precursors using Bu(3)SnH. The aminyl radicals generated by cyclisation onto imines undergo further 5- or 6-exo cyclisation with suitably placed alkenes. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：11445 / 11462

页数：18

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