Indicted: Worms caught using steroids

被引：24

作者：

Beckstead, RB ^{[1
]}

Thummell, CS ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Howard Hughes Med Inst, Dept Human Genet, Salt Lake City, UT 84112 USA

来源：

CELL | 2006年 / 124卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.03.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three recent papers provide new insights into endocrinology in the worm Caenorhabditis elegans. These studies identify natural steroid ligands for the DAF-12 nuclear receptor, define a new enzyme in the hormone biosynthetic pathway, and clarify the role of endocrine signaling in adult longevity.

引用

页码：1137 / 1140

页数：4

共 17 条

[1]

Antebi A, 2000, GENE DEV, V14, P1512

[2] Germ-cell loss extends C-elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling [J].

Berman, JR ;

Kenyon, C .

CELL, 2006, 124 (05) :1055-1068

[3] Hormonal signals produced by DAF-9/cytochrome P450 regulate C-elegans dauer diapause in response to environmental cues [J].

Gerisch, B ;

Antebi, A .

DEVELOPMENT, 2004, 131 (08) :1765-1776

[4] A hormonal signaling pathway influencing C-elegans metabolism, reproductive development, and life span [J].

Gerisch, B ;

Weitzel, C ;

Kober-Eisermann, C ;

Rottiers, V ;

Antebi, A .

DEVELOPMENTAL CELL, 2001, 1 (06) :841-851

[5] Lipophilic regulator of a developmental switch in Caenorhabditis elegans [J].

Gill, MS ;

Held, JM ;

Fisher, AL ;

Gibson, BW ;

Lithgow, GJ .

AGING CELL, 2004, 3 (06) :413-421

[6] Signals from the reproductive system regulate the lifespan of C-elegans [J].

Hsin, H ;

Kenyon, C .

NATURE, 1999, 399 (6734) :362-366

[7]

Jia KL, 2002, DEVELOPMENT, V129, P221

[8] The plasticity of aging: Insights from long-lived mutants [J].

Kenyon, C .

CELL, 2005, 120 (04) :449-460

[9] Less steroids make bigger flies [J].

King-Jones, K ;

Thummel, CS .

SCIENCE, 2005, 310 (5748) :630-631

[10] Tissue-specific activities of C-elegans DAF-16 in the regulation of lifespan [J].

Libina, N ;

Berman, JR ;

Kenyon, C .

CELL, 2003, 115 (04) :489-502

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