Cleaning Up: ER-Associated Degradation to the Rescue

被引：276

作者：

Brodsky, Jeffrey L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

来源：

CELL | 2012年 / 151卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MUTANT ALPHA-1-ANTITRYPSIN; IN-VITRO; PROTEIN; RETROTRANSLOCATION; DISLOCATION; REDUCTASE; DELIVERY; PATHWAY; CYTOSOL; DOMAIN;

D O I：

10.1016/j.cell.2012.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All cellular proteins are subject to quality control "decisions,'' which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).

引用

页码：1163 / 1167

页数：5

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