An extensive class of small RNAs in Caenorhabditis elegans

被引：2159

作者：

Lee, RC ^{[1
]}

Ambros, V ^{[1
]}

机构：

[1] Dartmouth Coll Sch Med, Dept Genet, Hanover, NH 03755 USA

来源：

SCIENCE | 2001年 / 294卷 / 5543期

关键词：

D O I：

10.1126/science.1065329

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary In abundance during C. elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse.

引用

页码：862 / 864

页数：3

共 13 条

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