An open-label trial of combination therapy with interferon β-1a and oral methotrexate in MS

被引：65

作者：

Calabresi, PA

Wilterdink, JL

Rogg, JM

Mills, P

Webb, A

Whartenby, KA

机构：

[1] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

[2] Brown Univ, Sch Med, Dept Clin Neurosci, Providence, RI 02912 USA

[3] Brown Univ, Sch Med, Dept Radiol, Providence, RI 02912 USA

来源：

NEUROLOGY | 2002年 / 58卷 / 02期

关键词：

D O I：

10.1212/WNL.58.2.314

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An open-label study was performed to evaluate the safety and efficacy of combination therapy with weekly oral methotrexate (20 mg) and interferon beta-1a (IFNbeta-1a) in 15 patients with MS who had experienced exacerbations while receiving IFNbeta monotherapy. Nausea was the only major side effect. A 44% reduction in the number of gadolinium-enhanced lesions seen on MRI scan was observed during combination therapy (p = 0.02). There was a trend toward fewer exacerbations. This combination therapy appears to be safe and well tolerated, and should be studied in a controlled trial.

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页码：314 / 317

页数：4

相关论文

共 10 条

[1] Multiple sclerosis: Immunotherapy [J].

Bibiana Bielekova ;

Roland Martin .

Current Treatment Options in Neurology, 1999, 1 (3) :201-219

[2] Intrarater and interrater reliability of the MS functional composite outcome measure [J].

Cohen, JA ;

Fischer, JS ;

Bolibrush, DM ;

Jak, AJ ;

Kniker, JE ;

Mertz, LA ;

Skaramagas, TT ;

Cutter, GR .

NEUROLOGY, 2000, 54 (04) :802-806

[3] Therapy of relapsing multiple sclerosis. Treatment approaches for nonresponders [J].

Cohen, JA ;

Carter, JL ;

Kinkel, RP ;

Schwid, SR .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 98 (01) :29-36

[4] Combination therapy in rheumatoid arthritis [J].

Goekoop, YPM ;

Allaart, CFR ;

Breedveld, FC ;

Dijkmans, BAC .

CURRENT OPINION IN RHEUMATOLOGY, 2001, 13 (03) :177-183

[5] LOW-DOSE (7.5-MG) ORAL METHOTREXATE REDUCES THE RATE OF PROGRESSION IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS [J].

GOODKIN, DE ;

RUDICK, RA ;

MEDENDORP, SV ;

DAUGHTRY, MM ;

SCHWETZ, KM ;

FISCHER, J ;

VANDYKE, C .

ANNALS OF NEUROLOGY, 1995, 37 (01) :30-40

[6] Combination therapy for treatment of multiple sclerosis [J].

Lublin, FD ;

Reingold, SC .

ANNALS OF NEUROLOGY, 1998, 44 (01) :7-9

[7] Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: A preventive strategy [J].

Pincus, T ;

O'Dell, JR ;

Kremer, JM .

ANNALS OF INTERNAL MEDICINE, 1999, 131 (10) :768-774

[8] Short-term evolution of new multiple sclerosis lesions enhancing on standard and triple dose gadolinium-enhanced brain MRI scans [J].

Rovaris, M ;

Mastronardo, G ;

Prandini, F ;

Bastianello, S ;

Comi, G ;

Filippi, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 164 (02) :148-152

[9] Axonal transection in the lesions of multiple sclerosis [J].

Trapp, BD ;

Peterson, J ;

Ransohoff, RM ;

Rudick, R ;

Mörk, S ;

Bö, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (05) :278-285

[10] INTERMITTENT CYCLOPHOSPHAMIDE PULSE THERAPY IN PROGRESSIVE MULTIPLE-SCLEROSIS - FINAL REPORT OF THE NORTHEAST-COOPERATIVE-MULTIPLE-SCLEROSIS-TREATMENT-GROUP [J].

WEINER, HL ;

MACKIN, GA ;

ORAV, EJ ;

HAFLER, DA ;

DAWSON, DM ;

LAPIERRE, Y ;

HERNDON, R ;

LEHRICH, JR ;

HAUSER, SL ;

TUREL, A ;

FISHER, M ;

BIRNBAUM, G ;

MCARTHUR, J ;

BUTLER, R ;

MOORE, M ;

SIGSBEE, B ;

SAFRAN, A .

NEUROLOGY, 1993, 43 (05) :910-918