Looking into anti-angiogenic gene therapies for disorders of the eye

被引：6

作者：

Rasmussen, HS ^{[1
]}

Rasmussen, CS ^{[1
]}

Durham, RG ^{[1
]}

King, CR ^{[1
]}

Wei, L ^{[1
]}

机构：

[1] GenVec, Gaithersburg, MD 20878 USA

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 22期

关键词：

D O I：

10.1016/S1359-6446(01)02034-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR) are the most common causes of visual impairment in the developed world. Because the key factor in AMD and DR is aberrant neovascularization in the retina (DR) or in the choroid (AMD), strategies to inhibit abnormal neovascularization represent a compelling therapeutic approach. Here we review various anti-angiogenic strategies for the treatment of ocular neovascular diseases with special emphasis on gene transfer as a way of achieving high, sustained concentrations of antiangiogenic proteins in the back of the eye without concomitant systemic toxicity.

引用

页码：1171 / 1175

页数：5

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