Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis

被引：36

作者：

Asamizu, S ^{[1
]}

Kato, Y ^{[1
]}

Igarashi, Y ^{[1
]}

Furumai, T ^{[1
]}

Onaka, H ^{[1
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Imizu, Toyama 9390398, Japan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 04期

关键词：

biosynthesis; indolocarbazole; staurosporine; chromopyrrolic acid; StaD; RebD; VioB; indole-3-pyruvic acid; heme;

D O I：

10.1016/j.tetlet.2005.11.061

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indole-3-pyruvic acid was transformed to chromopyrrolic acid by a novel heme-containing enzyme StaD responsible for staurosporine biosynthetic pathway in Streptomyces sp. TP-A0274. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：473 / 475

页数：3

共 7 条

[1] August PR, 2000, J MOL MICROB BIOTECH, V2, P513
[2] STUDIES ON THE BIOSYNTHESIS OF VIOLACEIN .4. A NEW METABOLITE OF TRYPTOPHAN, CHROMOPYRROLIC ACID, PRODUCED BY CHROMOBACTERIUM-VIOLACEUM
HOSHINO, T
KOJIMA, Y
HAYASHI, T
UCHIYAMA, T
KANEKO, K
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (05) : 775 - 781
[3] Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin
Klatt, P
Pfeiffer, S
List, BM
Lehner, D
Glatter, O
Bachinger, HP
Werner, ER
Schmidt, K
Mayer, B
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) : 7336 - 7342
[4] STAUROSPORINE, A POTENTIALLY IMPORTANT GIFT FROM A MICROORGANISM
OMURA, S
SASAKI, Y
IWAI, Y
TAKESHIMA, H
[J]. JOURNAL OF ANTIBIOTICS, 1995, 48 (07) : 535 - 548
[5] Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243
Onaka, H
Taniguchi, S
Igarashi, Y
Furumai, T
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (01) : 127 - 138
[6] Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp TP-A0274
Onaka, H
Asamizu, S
Igarashi, Y
Yoshida, R
Furumai, T
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2005, 69 (09) : 1753 - 1759
[7] The biosynthetic gene cluster for the antitumor rebeccamycin:: Characterization and generation of indolocarbazole derivatives
Sánchez, C
Butovich, IA
Braña, AF
Rohr, J
Méndez, C
Salas, JA
[J]. CHEMISTRY & BIOLOGY, 2002, 9 (04): : 519 - 531

← 1 →