Seizures and their outcome in progressive multifocal leukoencephalopathy

被引：75

作者：

Lima, MA

Drislane, FW

Koralnik, IJ

机构：

[1] Harvard Univ, Dept Neurol, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

[2] Harvard Univ, Div Viral Pathogenesis, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

[3] Fed Univ Rio De Janeiro, Sch Med, Rio De Janeiro, Brazil

来源：

NEUROLOGY | 2006年 / 66卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000194227.16696.11

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival. The presence of PML lesions immediately adjacent to the hemispheric cortex was the only risk factor associated with seizures in this population.

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页码：262 / 264

页数：3

相关论文

共 10 条

[1] Progressive multifocal leukoencephalopathy and natalizumab - Unforeseen consequences [J].

Berger, JR ;

Koralnik, IJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (04) :414-416

[2] The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: Defining a consensus terminology [J].

Cinque, P ;

Koralnik, IJ ;

Clifford, DB .

JOURNAL OF NEUROVIROLOGY, 2003, 9 (Suppl 1) :88-92

[3] Clinical and physiological features of epilepsia partialis continua - Cases ascertained in the UK [J].

Cockerell, OC ;

Rothwell, J ;

Thompson, PD ;

Marsden, CD ;

Shorvon, SD .

BRAIN, 1996, 119 :393-407

[4] Levetiracetam for seizures after liver transplantation [J].

Glass, GA ;

Stankiewicz, J ;

Mithoefer, A ;

Bergethon, PR .

NEUROLOGY, 2005, 64 (06) :1084-1085

[5] PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) - A NEUROPATHOLOGICAL AUTOPSY STUDY OF 21 CASES [J].

KUCHELMEISTER, K ;

GULLOTTA, F ;

BERGMANN, M ;

ANGELI, G ;

MASINI, T .

PATHOLOGY RESEARCH AND PRACTICE, 1993, 189 (02) :163-173

[6] AIDS-ASSOCIATED PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY REVEALED BY NEW-ONSET SEIZURES [J].

MOULIGNIER, A ;

MIKOL, J ;

PIALOUX, G ;

FENELON, G ;

GRAY, F ;

THIEBAUT, JB .

AMERICAN JOURNAL OF MEDICINE, 1995, 99 (01) :64-68

[7] LESION LOCALIZATION IN PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES - GRAY OR WHITE-MATTER [J].

RAROQUE, HG ;

PURDY, P .

EPILEPSIA, 1995, 36 (01) :58-62

[8] Infection with JC virus and possible dysplastic ganglion-like transformation of the cerebral cortical neurons in a case of progressive multifocal leukoencephalopathy [J].

Shintaku, M ;

Matsumoto, R ;

Sawa, H ;

Nagashima, K .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (10) :921-929

[9] Epileptic and non-epileptic seizures in multiple sclerosis [J].

Spatt, J ;

Chaix, R ;

Mamoli, B .

JOURNAL OF NEUROLOGY, 2001, 248 (01) :2-9

[10] Epileptic seizures in multiple sclerosis: clinical and EEG correlations [J].

Striano, P ;

Orefice, G ;

Brescia Morra, V ;

Boccella, P ;

Sarappa, C ;

Lanzillo, R ;

Vacca, G ;

Striano, S .

NEUROLOGICAL SCIENCES, 2003, 24 (05) :322-328