Biosynthesis and genetics of ADP-heptose

被引：10

作者：

Valvano, MA ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 1999年 / 5卷 / 1-2期

关键词：

D O I：

10.1177/09680519990050010901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycero-manno-heptose is a common component in the lipopolysaccharide (LPS) of many Gramnegative bacteria. Mutants deficient in the synthesis of glycero-manno-heptose are highly sensitive to hydrophobic compounds, and display reduced virulence, making these genes and their products potential targets for developing novel antimicrobials. To date, the biosynthesis of the heptosyl precursors for the inner core oligosaccharide of the LPS molecule is not completely characterized. In this work, the genes and enzyme functions involved in the various steps of the biosynthesis of ADP-L-glycero-D-manno-heptose are discussed, especially those involved in the intermediate steps.

引用

页码：90 / 95

页数：6

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