Metformin: a case of divide and conquer

被引：6

作者：

Anastasiou, Dimitrios ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Physiol & Metab, London NW7 1AA, England

来源：

BREAST CANCER RESEARCH | 2013年 / 15卷 / 02期

基金：

英国医学研究理事会;

关键词：

CANCER-CELLS; STEM-CELLS; INFLAMMATION; EQUILIBRIUM;

D O I：

10.1186/bcr3387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metformin is a widely prescribed anti-diabetic drug and its use is associated with lower cancer incidence. The mechanisms by which metformin attenuates tumorigenesis are not clearly understood. In a paper published in Proceedings of the National Academy of Sciences of the United States of America, Hirsch and colleagues show that metformin interferes with a signaling pathway, mediated by the transcription factor NF-kappa B, which drives cell transformation and is required for the maintenance of cancer stem cells.

引用

页数：3

共 15 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2] Tumour stem cells and drug resistance [J].

Dean, M ;

Fojo, T ;

Bates, S .

NATURE REVIEWS CANCER, 2005, 5 (04) :275-284

[3] NF-κB and the link between inflammation and cancer [J].

DiDonato, Joseph A. ;

Mercurio, Frank ;

Karin, Michael .

IMMUNOLOGICAL REVIEWS, 2012, 246 :379-400

[4] Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells [J].

Gupta, Piyush B. ;

Fillmore, Christine M. ;

Jiang, Guozhi ;

Shapira, Sagi D. ;

Tao, Kai ;

Kuperwasser, Charlotte ;

Lander, Eric S. .

CELL, 2011, 146 (04) :633-644

[5] Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening [J].

Gupta, Piyush B. ;

Onder, Tamer T. ;

Jiang, Guozhi ;

Tao, Kai ;

Kuperwasser, Charlotte ;

Weinberg, Robert A. ;

Lander, Eric S. .

CELL, 2009, 138 (04) :645-659

[6] AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern [J].

Hardie, D. Grahame ;

Ross, Fiona A. ;

Hawley, Simon A. .

CHEMISTRY & BIOLOGY, 2012, 19 (10) :1222-1236

[7] Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth [J].

Hirsch, Heather A. ;

Iliopoulos, Dimitrios ;

Struhl, Kevin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (03) :972-977

[8] Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission [J].

Hirsch, Heather A. ;

Iliopoulos, Dimitrios ;

Tsichlis, Philip N. ;

Struhl, Kevin .

CANCER RESEARCH, 2009, 69 (19) :7507-7511

[9] Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types [J].

Iliopoulos, Dimitrios ;

Hirsch, Heather A. ;

Struhl, Kevin .

CANCER RESEARCH, 2011, 71 (09) :3196-3201

[10] Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion [J].

Iliopoulos, Dimitrios ;

Hirsch, Heather A. ;

Wang, Guannan ;

Struhl, Kevin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (04) :1397-1402

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