Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population

被引:55
作者
Cornelius, C
Fastbom, J
Winblad, B
Viitanen, M
机构
[1] Stockholm Gerontol Res Ctr, Aging Res Ctr, Div Geriatr Epidemiol, Neurotec,Karolinska Inst, S-11382 Stockholm, Sweden
[2] Huddinge Univ Hosp, Div Geriatr Med, Stockholm, Sweden
关键词
anti-inflammatory drugs; aspirin; non-steroidal anti-inflammatory drugs; Alzheimer's disease; dementia; apolipoprotein E; cohort study;
D O I
10.1159/000075957
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In a cohort study, 1,301 subjects free of dementia at baseline in the Kungsholmen Project were followed up to 6 years. We studied the association between use of aspirin and non-steroidal anti-inflammatory drugs ( NSAIDs), incidence of Alzheimer's disease ( AD) and overall dementia, and the influence of the apolipoprotein E epsilon4 allele. In stratified analyses, a relative risk (RR) of 1.80 (95% CI 1.14 - 2.83) for AD was seen, in the apoE epsilon4-negative group using aspirin. This implicates a possible different mechanism of developing AD in this group. We also found a possible protective effect of NSAIDs against AD, since no one who used NSAIDs for around 3 years had developed AD 3 years later. One user developed vascular dementia, and a low point value of risk was seen, however, not significant (RR 0.23; 95% CI 0.03 - 1.68). This could be due to the small samples in our study, or to comorbidity contributing to the development of dementia in this elderly population. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:135 / 143
页数:9
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