Preparation and thermosensitivity of naturally occurring polypeptide poly(γ-glutamic acid) derivatives modified by propyl groups

被引：29

作者：

Shimokuri, T

Kaneko, T

Serizawa, T

Akashi, M

机构：

[1] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostruct & Adv Mat, Kagoshima 8900065, Japan

[2] Japan Sci & Technol Agcy JST, CREST, Tokyo, Japan

来源：

MACROMOLECULAR BIOSCIENCE | 2004年 / 4卷 / 04期

关键词：

biodegradable; esterification; peptides; phase separation; stimuli-sensitive polymers;

D O I：

10.1002/mabi.200300073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(gamma-glutamic acid) (gamma-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(alpha-propyl gamma-glutamate) (gamma-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the gamma-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the gamma-PGA polymeric chains.

引用

页码：407 / 411

页数：5

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