Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees

被引：8

作者：

Swift-Scanlan, T

Lan, TH

Fallin, MD

Coughlin, JM

Potash, JB

DePaulo, JR

McInnis, MG

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, George Browne Genet Lab, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

来源：

PSYCHIATRIC GENETICS | 2002年 / 12卷 / 01期

关键词：

trinucleotide repeat; bipolar disorder; multifactorial disorder; complex disease; association study;

D O I：

10.1097/00041444-200203000-00006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A strong genetic association between the NOTCH4 locus on chromosome 6 and schizophrenia was recently reported. Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)(n) encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. In addition, we analyzed a subset of our pedigrees with psychotic features at this locus. We failed to find any association between the (CTG)(n) NOTCH4 polymorphism and either the bipolar or the psychotic bipolar phenotype in our 65 pedigrees.

引用

页码：43 / 47

页数：5

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