The cohesin complex and its roles in chromosome biology

被引：385

作者：

Peters, Jan-Michael ^{[1
]}

Tedeschi, Antonio ^{[1
]}

Schmitz, Julia ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 22期

基金：

奥地利科学基金会;

关键词：

Cohesin; sister chromatid cohesion; chromosome; mitosis; meiosis; cell cycle;

D O I：

10.1101/gad.1724308

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repair of damaged DNA and has important functions in regulating gene expression in both proliferating and post-mitotic cells. Here we discuss how cohesin associates with DNA, how these interactions are controlled during the cell cycle; how binding of cohesin to DNA may mediate sister chromatid cohesion, DNA repair, and gene regulation; and how defects in these processes can lead to human disease.

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收藏

页码：3089 / 3114

页数：26

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