An antibody that prevents the hemagglutinin low pH fusogenic transition

被引：133

作者：

Barbey-Martin, C

Gigant, B

Bizebard, T

Calder, LJ

Wharton, SA

Skehel, JJ

Knossow, M

机构：

[1] Lab Enzymol & Biochim Struct, CNRS, UPR 9063, F-91198 Gif Sur Yvette, France

[2] Natl Inst Med Res, London NW7 1AA, England

来源：

VIROLOGY | 2002年 / 294卷 / 01期

关键词：

influenza; membrane fusion; hemagglutinin; structure; antibody;

D O I：

10.1006/viro.2001.1320

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition. (C) 2002 Elsevier Science (USA).

引用

页码：70 / 74

页数：5

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