Ovine atadenovirus: a review of its biology, biosafety profile and application as a gene delivery vector

被引：25

作者：

Both, GW ^{[1
]}

机构：

[1] CSIRO Mol Sci, N Ryde, NSW 2113, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2004年 / 82卷 / 02期

关键词：

gene delivery; gene function; ovine atadenovirus; prostate cancer; vaccine; vector;

D O I：

10.1046/j.0818-9641.2004.01223.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ovine adenovirus isolate OAdV287 is the prototype of the newly recognized genus of atadenoviruses. Although not as well studied as human mastadenoviruses, a substantial amount of work has now been carried out with this virus and an understanding of its interesting and unique properties is beginning to emerge. In this article the biology and biosafety profile of the virus is reviewed. This knowledge underpins the exploitation of the virus as a gene delivery vector. Its potential as a vaccine vector and its application to the treatment of prostate cancer is summarized and discussed.

引用

页码：189 / 195

页数：7

共 56 条

[1]

[Anonymous], 1990, VIROLOGY

[2] SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box [J].