Retinoids: novel immunomodulators and tumour-suppressive agents?

被引：24

作者：

Carratu, M. R. ^{[2
]}

Marasco, C. ^{[2
]}

Mangialardi, G. ^{[1
]}

Vacca, A. ^{[2
]}

机构：

[1] Univ Bristol, Regenerat Med Sect, Sch Clin Sci, Bristol, Avon, England

[2] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 167卷 / 03期

关键词：

retinoids; immune disorders; malignancy; ACTIVATED-RECEPTOR-GAMMA; NF-KAPPA-B; ACUTE MYELOID-LEUKEMIA; NERVE GROWTH-FACTOR; HUMAN HEPATOCELLULAR-CARCINOMA; ACUTE PROMYELOCYTIC LEUKEMIA; HIGH-RISK NEUROBLASTOMA; HUMAN PROSTATE-CANCER; TGF-ALPHA EXPRESSION; MESSENGER-RNA LEVELS;

D O I：

10.1111/j.1476-5381.2012.02031.x

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Retinoids play important roles in the transcriptional activity of normal, degenerative and tumour cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and systemic lupus erythematosus. In addition, the use of retinoids in cancer treatment has progressed significantly in the last two decades; thus, numerous retinoid compounds have been synthesized and tested. In this paper, the actual or potential use of retinoids as immunomodulators or tumour-suppressive agents is discussed.

引用

页码：483 / 492

页数：10

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